Differentiation and IL-12 Signaling and Human IL-12-Dependent Th1 Selective Pharmacologic Inhibition of Murine
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Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12
The pro-Th2 cytokine IL-33 is now emerging as an important Th1 cytokine-IFN-γ inducer in murine CD4(+) T cells that is essential for protective cell-mediated immunity against viral infection in mice. However, whether IL-33 can promote human Th1 cell differentiation and how IL-33 polarizes Th1 cells is less understood. We assessed the ability of IL-33 to induce Th1 cell differentiation and IFN-γ...
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تاریخ انتشار 1999